I run Conti GP4000S2s on my road bike (and tubeless with various tires on my CX bike), and the only puncture I've had in the last two years is one on my CX bike that was large enough the sealant wouldn't fix it.
Edit: I forgot, I also got one pinch flat on my CX bike too (the same ride as the puncture, actually!) due to a *very* poorly executed bunny hop over a pot hole (my rear wheel ended up landing squarely *in* the pot hole).
Edit: I forgot, I also got one pinch flat on my CX bike too (the same ride as the puncture, actually!) due to a *very* poorly executed bunny hop over a pot hole (my rear wheel ended up landing squarely *in* the pot hole).